High-quality data supporting health management decisions are key to effective governance, leadership, and management. However, new global and international strategies and the development of tools and mechanisms should be promoted to highly integrate platforms among European countries. (4) Conclusions: RHIS interventions in the European region are promising. We have found different areas for improvement for RHISs according to the three determinants of the PRISM framework that influence the configuration of RHISs: technical, organizational, or behavioral elements. All reviews examined showed variability in results in accordance with the variability of interventions and target populations. (3) Results: The reviews were published between 20, focusing on the use of different systems or technologies and aimed to analyze interventions on professionals, centers, or patients’ outcomes. After a meticulous screening, we identified 20 that met the inclusion criteria, and RHIS evaluation results were presented according to the Performance of Routine Information System Management (PRISM) framework. (2) Methods: We conducted an overview of systematics reviews and searched the literature in the databases MEDLINE/PubMed, Cochrane, EMBASE, and Web of Science electronic databases. (1) Background: The aim of this study is to provide a better understanding of the requirements to improve routine health information systems (RHISs) for the management of health systems, including the identification of best practices, opportunities, and challenges in the 53 countries and territories of the WHO European region.
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